Road Policing officers in Aberdeen are appealing for information following the crash, which happened around 12.40am this morning (Saturday, July 31).
The crash happened around one mile after the Rob Roy Bridge. A grey Audi A6 was found on its roof and had caught fire.
Emergency services attended the scene and one man, aged 18, was taken to Aberdeen Royal Infirmary with life-changing injuries.
A 27-year-old man was taken to hospital having suffered serious injuries, and a 19-year-old man was taken for treatment to minor injuries.
The road was closed to allow police officers to carry out enquiries, and it has remained closed to allow the road surface to be repaired.
Sergeant Chris Smith, from the road policing unit said: "We continue to investigate the circumstances of this road crash and it is important we establish exactly what happened at the time of the crash and in the moments leading up to it.
"If you witnessed the crash and have yet to speak to police officers, then please get in touch. If you were driving in the area before 12.40am and saw a car matching this description, please also come forward. We would also like to speak to anyone who has dash-cam or CCTV footage which assist with our investigation."
Information can be provided by calling police on 101, and quoting reference number 0138 of 31 July.